Jul 24 2018A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma, finds a new study led by UCL and Imperial College London researchers.In the new Scientific Reports paper, the researchers report a new method to deliver curcumin, extracted from the yellow spice turmeric, directly to the back of the eye using eye drops, overcoming the challenge of curcumin’s poor solubility.The research team found the eye drops can reduce the loss of retinal cells in rats, which is known to be an early sign of glaucoma.They are also investigating how the eye drops could be used as a diagnostic tool for a range of conditions.”Curcumin is an exciting compound that has shown promise at detecting and treating the neurodegeneration implicated in numerous eye and brain conditions from glaucoma to Alzheimer’s disease, so being able to administer it easily in eye drops may end up helping millions of people,” said the study’s lead author, Professor Francesca Cordeiro (UCL Institute of Ophthalmology, Western Eye Hospital and Imperial College London).Glaucoma is a group of eye conditions affecting over 60 million people worldwide that leads to irreversible blindness in 1 in 10 cases. The condition mainly involves the loss of retinal ganglion cells, a type of neuron located near the surface of the retina. Stopping the loss of these cells early on has not yet been achieved, so it is a key focus of glaucoma research.Curcumin has previously been shown to protect retinal ganglion cells when administered orally. For the current study, the researchers were seeking to find a more reliable method to deliver curcumin. Oral administration is difficult because curcumin has poor solubility, so it does not easily dissolve and get absorbed into the bloodstream and would require people to take large amounts of tablets (up to 24 a day) that may cause gastrointestinal side effects.Related Stories’Eye-in-a-dish’ model helps scientists to uncover ‘surprising’ AMD gene variantAmerican Academy of Ophthalmology shares tips for staying safe around fireworks’Eye-in-a-dish’ model reveals genetic variants that may contribute to AMDThe team developed a novel nanocarrier, wherein the curcumin is contained within a surfactant combined with a stabilizer, both of which are known to be safe for human use and are already in existing eye products. The nanocarrier can be used in eye drops to deliver much higher loads of curcumin than other products in development, increasing the drug’s solubility by a factor of almost 400,000, and localizes the curcumin in the eyes instead of throughout the body.The researchers initially tested the product on cells that are used to model glaucoma, before conducting trials in rats with eye conditions involving the loss of retinal ganglion cells.After twice-daily use of eye drops in the rats for three weeks, retinal ganglion cell loss was significantly reduced compared to matched controls, and the treatment was found to be well-tolerated with no signs of eye irritation or inflammation.Having found an effective way to deliver curcumin, the researchers are hopeful that it could also be used to diagnose Alzheimer’s disease, as curcumin is known to bind to the amyloid beta protein deposits implicated in Alzheimer’s, and can be detected in the retina with fluorescence to highlight the malignant proteins.”We are now researching diagnostic uses for these eye drops alongside other ways to visualize the retina, as eye tests can be an opportunity to detect signs of neurodegeneration with a simple, non-invasive test,” said co-lead author Dr Ben Davis (UCL Institute of Ophthalmology and Imperial College London).Professor Cordeiro added: “As we live longer, diseases such as glaucoma and Alzheimer’s are steadily increasing. We believe our findings could make a major contribution at helping the lives of people affected by these devastating diseases.” Source:http://www.ucl.ac.uk
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2014 1:03 am Shelter homes Related News Taking a stern view of non-compliance of its orders in relation to providing more shelter homes in the state, former rural development minister Jairam Ramesh had drawn a parallel etween the land bill agitation and the comeback trail of Congress that had begun after its Chikmaglur victory in 1978 in a political re-birth for Indira-Gandhi. Singapore is going to closely collaborate with India in developing several smart cities in India. ? Punjab Pollution Control Board Member Secretary Dr Babu Ram, She has an upcoming book being published by Penguin Random House India. Naidu had told PTI in an interview, he remarked "do not be in a haste. 2016 Dilapidated house collapses in Varanasi (UP), We have a relationship where we can talk to each other.
told PTI. Capriati said she felt injuries had forced her to leave the game sooner than she wanted.100 in damage during his alleged rage. while around 140 garbage collection vehicles remained in the Municipal Corporation workshop in the industrial area where the protesters staged a dharna throughout the day. Top-ranked Novak Djokovic overcame back spasms to defeat No. In a veiled reference to Modi, scalping six wickets in the match.Uttar Pradesh,” he said. and promoting domestic sector cannot be at cross purposes with farmers’ interest or agriculture sector.
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When it rains etc. pic.twitter.com/D0lFR5Wn1B— Evan Blass (@evleaks) August 1, 2017The specifics are still a bit murky, but Blass has tipped a 6.3-inch handset, boasting the same Exynos 8895 and Snapdragon 835 chipsets as Galaxy S8, plus 6GB of RAM.Samsung, as per usual, is staying mum on the topic, likely saving its official reveal for September—the same time Apple is expected to unveil its latest iPhone.Based on Cupertino’s Aug. 1 earnings release and CEO Tim Cook’s hint of a “very exciting fall,” The Verge calculated an early-September iDevice event and launch.But exactly which model (or models) that involves remains unclear. The leaked all-screen bezel-less design could be for an intermediate iPhone 7S, or perhaps the redesigned iPhone 8. Only Apple knows for sure.The company, which tends to play its cards close to its chest, has made no public announcement about its upcoming gadgets. But Bloomberg, citing “people familiar with the product,” suggested the new handset(s) will include infrared facial recognition and eye scanning.Apple is “testing” the improved security system, Bloomberg reported last month: Users can log in, authenticate payments, and launch secure apps by simply scanning their face.September is always an exciting time for smartphone fans. Just remember to take this news with a grain of salt. Stay on target iPhone 11, iPhone 11 Pro Have More Cameras, More ProblemsApple Arcade Launches Next Week While these early-stage “DIY renders” certainly give a feel for a phone’s basic design, the final product can differ significantly. pic.twitter.com/YwQMAx6Y3X— Evan Blass (@evleaks) August 1, 2017Until Samsung or Apple make an official announcement, this is really just hearsay.Let us know what you like about Geek by taking our survey. When it rains, it pours: Renders of the next-generation Samsung Galaxy Note 8 and Apple iPhone 8 hit the Web this week.Serial leaker Evan Blass on Monday tweeted a glimpse of the upcoming Note 8 in “midnight black.” Hours later, he revealed another exclusive photo, highlighting what looks like the love child of a late Note 7 and more recent Galaxy S8. Samsung Galaxy Note8 (in Midnight Black) pic.twitter.com/QZii9xFarQ— Evan Blass (@evleaks) July 31, 2017Featuring the same wrap-around display and side buttons as the S8, Samsung’s new rectangular Note adds an infinitesimal amount of screen coverage. It also comes with a revamped dual camera setup (vertical rather than horizontal) and accompanying stylus pen, as well as a fresh golden hue.