Jan 9 2019Faulty wiring of the prefrontal cortex during development leads to abnormal brain activity and cognitive impairments related to mental illness, according to a mouse study published in JNeurosci. Source:http://www.sfn.org/ Eliminating a molecule called Disrupted-in-Schizophrenia 1 (DISC1) from the entire brain has been previously shown to alter connectivity between the prefrontal cortex and the hippocampus and impair the cognitive abilities this circuit supports in mice exposed to an environmental stressor. Ileana Hanganu-Opatz and colleagues now show similar deficits arise from disrupting DISC1 in a specific group of prefrontal cortex neurons in mouse embryos whose mothers were infected with a virus. These findings uncover a molecular mechanism by which abnormal development of the prefrontal cortex and maternal stress interact to produce brain and behavior impairments reminiscent of schizophrenia, bipolar, and depressive disorders.
0% District 8 Supervisor Jeff Sheehy, whose district covers the western side of Valencia Street, showed his support for barriers between bike lanes and drivers by joining the activists standing on the painted lane divider. His first job, he said, was as a bike messenger — a knee injury keeps him off his bike these days, but he understands the safety concern. He and District 9 Supervisor Hillary Ronen have both called for protected bike lanes in the past.District 8 Supervisor Jeff Sheehy joins bike safety advocates on Valencia Street. Photo by Laura WenusHe’s heard a number of proposals, including bike lanes in the center of the roads, or installing some kind of barrier between the vehicle and bicycle lanes.“It doesn’t matter to me which solution it is, but we do need a solution,” he said.But creating a barrier could get tricky when it comes to public opinion. As Kyle Grochmal, one of the cycling advocates out on the street Thursday, pointed out, a five-foot buffer requirement between parking and bike lanes would mean that a good portion of Valencia would have to have parking only on one side of the street, because the road simply isn’t wide enough to accommodate two parking lanes, two bike lanes and two driver lanes.But Sheehy said once the cycling community comes to a consensus and pushes for what form it really wants, he’d be supportive — even if there is a parking concern.“Safety’s more important than parking,” he said. “You’ve got to have a hierarchy.”The San Francisco Municipal Transit Agency is looking at funding protected bike lanes, an action which would need approval from the agency’s Board of Directors as well as the Board of Supervisors. The yellow-shirted bicycle-safety activists were back on Valencia Street between 18th and 19th streets Thursday afternoon, carrying signs that read: “Protected lane.”Their aim is to get something built on Valencia that physically separates cyclists and drivers on the road to avoid collisions.As it stands, the street has painted bike lanes, but nothing stops drivers from rolling into them to make a “quick” stop — to dash into a restaurant and pick up a takeout order, to pick up a group of drunk ride-hail passengers, or to drop off a friend or delivery.That’s the source of much chagrin among cyclists, and in some cases, leads to collisions. Tags: bikes • valencia street Share this: FacebookTwitterRedditemail,0%
Staff Writer. Covers leadership, media, technology and culture. Uber Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Uber Is Eating Up Taxi Rides in New York City –shares 2 min read Next Article Nina Zipkin October 20, 2015 Add to Queue Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Entrepreneur Staff Though Uber is often on the receiving end of controversy, it seems that its growth in major markets, particularly in New York, can’t be stopped.The ridesharing service saw an increase of about 3.82 million pickups in Manhattan from May to June of this year, while taxis saw a decline of 3.83 million pickups over the same time, according to a data analysis by FiveThirtyEight. Uber now carries out 13 percent of all hired rides in New York City, up from 4 percent, according to the analysis.In New York City, Uber drivers and their vehicles must be registered with the Taxi & Limousine Commission. Uber drivers, however, do not need to purchase one of the city’s prized taxi medallions, which are often hundreds of thousands of dollars. Uber’s rise in New York has meant that licensed cab drivers no longer have to be hemmed in by the cost of those medallions. The number of medallion drivers licensed to drive cabs in the city is down 2.2 percent from the end of 2014, a TLC spokesperson told FiveThirtyEight.Read more: Uber Cars Have Overtaken Yellow Taxis in New York CityWhile Uber has operated in New York City since 2011, the conversation around the ridesharing company has been particularly fraught over the last several months. The summer saw New York City Mayor Bill de Blasio propose and then drop a bill to cap the number of Uber vehicles in the city, while New York Governor Andrew Cuomo and New York City Comptroller Scott Stringer came out in favor of Uber’s growth in the city.As part of the cap legislation getting scuttled, Uber agreed to turn over company data to the city so it could carry out a four-month investigation of the impact of ridesharing services and for-hire vehicles on traffic, pollution and other transportation issues in the five boroughs.Uber isn’t only taking significant strides in New York City. In Portland, Ore., the city’s Bureau of Transportation released its own findings this week which saw cab rides fall by 16 percent from May to August, while Uber and Lyft rides increase by 125 percent. On-demand rides made up 60 percent of all rides around Portland at the end of August. Related: What You Need to Know to Compete With the Surging Sharing Economy Enroll Now for $5
May 2 2018An estimated 45 percent of people are at risk of developing knee osteoarthritis (OA) in their lifetime. According to a network meta-analysis research article published in the May 1, 2018 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), the nonsteroidal anti-inflammatory drug (NSAID) naproxen was ranked most effective in individual knee OA treatment for improving both pain and function, and is considered a relatively safe and low-cost treatment method.Nonsurgical treatments for knee OA supported by previous research evidence include strength training, low-impact aerobic exercises, NSAIDs, and weight loss in individuals with a body mass index over 25. This new research analyzed data from multiple trials to determine the relative effectiveness of various nonsurgical treatments for knee OA. The treatments that were compared and ranked included acetaminophen; ibuprofen; intra-articular (IA) or joint injections of cortisone; platelet-rich plasma (PRP); hyaluronic acid (HA); several NSAIDs, such as naproxen, celecoxib, and diclofenac; and both oral and IA placebo.”This is the first comprehensive mixed-comparison analysis comparing best-evidence scientific research and excluding lower quality studies that can bias the outcomes,” said lead author and orthopedic surgeon David Jevsevar, MD, MBA. “Using a statistical ranking technique, we worked to provide evidence regarding which of the most common NSAIDs are most likely to decrease pain and improve function, and we attempted to fill in the gaps in evidence for more inconclusive treatments such as HA, PRP, and corticosteroids.”Authors analyzed 53 randomized controlled trials that examined knee OA treatments for at least 28 days and included a minimum of 30 participants per study group. Knee OA treatments were ranked on a scale of one to five, with one being the most effective. They found the following:Related StoriesArthroscopy more accurate than MRI for chondral defects of the knee, study findsTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTResearch sheds light on sun-induced DNA damage and repair For pain reduction, cortisone injections provided the greatest short-term (4 to 6 weeks) pain relief, followed by ibuprofen, PRP injections, naproxen, and celecoxib. Naproxen ranked the highest for probability for improving function, followed by diclofenac, celecoxib, ibuprofen, and PRP injections. Naproxen was ranked the most effective individual knee OA treatment for improving both pain and function followed by cortisone injections, PRP injections, ibuprofen and celecoxib. HA injections did not achieve a rank in the top five treatments for pain, function, or combined pain and function. An analysis of 12 articles also found that results with HA are not significantly different from those with IA placebo for treatment of knee OA. Source:http://newsroom.aaos.org/media-resources/news/non-surgical-treat-of-knee-osteoarthritis.htm “Because knee OA has both a high disease burden and high treatment costs, additional prospective studies using similar outcomes, timelines, and measures of clinically important changes are needed,” explained Dr. Jevsevar. “While the information in this analysis is helpful to physicians, patients also can benefit from these findings and use it with their doctors to weigh all possible treatment options.”Although the use of NSAIDs for arthritic conditions such as knee OA has potential risks, including heart attack and stroke, existing evidence indicates that naproxen has less potential for adverse cardiovascular events.